Tuberous Sclerosis Topics

• ultrasound scanning
• symptomatic cases
• learning disability
• clinical signs
• genetic diseases
• rare disease
• total population
• prevalence
• seizures
• manifestations
• triad
• invention
• diagnosis

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Tuberous Sclerosis, Tuberous Sclerosis

The following table shows the prevalence of some of the clinical signs in individuals diagnosed with tuberous sclerosis.

Hence, awareness regarding differentorgan manifestations of tuberous sclerosis is important.

The reason is that the invention of CT and ultrasound scanning have enabled the diagnosis of many non-symptomatic cases. Prior to this, the diagnosis of tuberous sclerosis was largely restricted to severely affected individuals with Vogt's triad of learning disability, seizures and facial angiofibroma. The total population prevalence figures have steadily increased from 1:150,000 in 1956, to 1:100,000 in 1968, to 1:70,000 in 1971, to 1:34,200 in 1984, to the present figure of 1:12,500 in 1998. Whilst still regarded as a rare disease, it is common when compared to many other genetic diseases.

Source: Wikipedia > Tuberous Sclerosis