Toxic Shock Syndrome Topics

• mhc molecule
• staphylococcus aureus
• toxic shock syndrome toxin
• antigen presenting cells
• causative bacteria
• using tampons
• streptococcus pyogenes
• s aureus
• multisystem disease
• cell population
• superantigens
• t cells
• tsst
• cytokine storm
• polyclonal
• tss
• t cell
• illnesses
• girls

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Toxic Shock Syndrome, Toxic Shock Syndrome

Different bacteria toxins may cause toxic shock syndrome, depending on the situation. The causative bacteria include Staphylococcus aureus and Streptococcus pyogenes . Streptococcal TSS is sometimes referred to as Toxic shock-like syndrome ( TSLS ).

The authors of the study noted that reports of similar staphylococcal illnesses had appeared occasionally as far back as 1927. But the authors at the time failed to consider the possibility of a connection between toxic shock syndrome and tampon use, as three of the girls who were menstruating when the illness developed were using tampons. Many cases of TSS occurred after tampons were either left in or lost inside the woman.

By contrast, superantigens do not require processing by antigen-presenting cells but instead interact directly with the invariant region of the class II MHC molecule. In patients with TSS, up to 20% of the body's T cells can be activated at one time. This polyclonal T-cell population causes a cytokine storm, followed by a multisystem disease. The toxin in S. aureus infections is Toxic Shock Syndrome Toxin-1, or TSST-1.

Source: Wikipedia > Toxic Shock Syndrome