Tamoxifen Topics

• pre cancerous cells
• judah folkman
• harvard medical school
• harvard researchers
• phases of the cell cycle
• s hospital
• angiogenesis inhibitors
• cancer research
• cell death
• doxycycline
• new blood
• golden retriever
• blood vessels
• myriad
• clinical trials
• researcher
• cocktail
• protocol
• navy

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Tamoxifen, Tamoxifen

Judah Folkman, a researcher at Children's Hospital at Harvard Medical School in Boston. Folkman discovered in the 1970s that angiogenesis the growth of new blood vessels plays a significant role in the development of cancer. Since his discovery, an entirely new field of cancer research has developed. Clinical trials on angiogenesis inhibitors have been underway since 1992 using a myriad of different drugs. The Harvard researchers developed a specific protocol for a golden retriever named Navy who was cancer-free after receiving the prescribed cocktail of celecoxib, doxycycline, and tamoxifen the treatment subsequently became known as the Navy Protocol.

Tamoxifen causes cells to remain in the G 0 and G 1 phases of the cell cycle. Because it prevents (pre)cancerous cells from dividing but does not cause cell death, tamoxifen is cytostatic rather than cytocidal.

Source: Wikipedia > Tamoxifen