Patients under treatment ought to avoid taking calcium and iron supplements within 4 hours, Ruth H. Michel, Patricia J. Neafsey, Laura Cox Dzurec: Self Medication Practices among Patients taking Levothyroxine. The Internet Journal of Advanced Nursing Practice. 2004. Volume 6 Number 2 as well as soy products within 3 hours of the medication, as these can reduce absorption of the drug. Other substances that reduce absorption are aluminium and magnesium containing antacids, simethicone or sucralfate, cholestyramine, colestipol, Kayexalate. Recently, it has been discovered that caffeine may also interfere with the intestinal absorption of levothyroxine.
Ketamine may cause hypertension and tachycardia and tricyclic and tetracyclic antidepressants increase its toxicity. On the other hand Lithium can cause hyperthyroidism (but most often hypothyroidism) by affecting iodine metabolism of the thyroid itself and thus inhibits synthetic levothyroxine as well.
Source: Wikipedia > Levothyroxine
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