Leishmaniasis Topics

• visceral leishmaniasis
• miltefosine
• vital organs
• regulatory authorities
• immunosuppressed
• saudi arabia
• phase iii
• preliminary results
• parasite
• gulf war
• kabul
• sanitation
• clinical trials
• parasites
• efficacy
• hiv
• colombia
• afghanistan
• drugs
• iraq

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Leishmaniasis, Leishmaniasis

Visceral leishmaniasis is a severe form in which the parasites have migrated to the vital organs.

Within Afghanistan, leishmaniasis occurs commonly in Kabul- partly due to bad sanitation and waste left uncollected in streets, allowing parasite-spreading sand flies an environment they find favorable.

Leishmaniasis has been reported by U.S. troops stationed in Saudi Arabia and Iraq since the Gulf War of 1990, including visceral leishmaniasis.

The cure rate of miltefosine in phase III clinical trials is 95%; Studies in Ethiopia show that it is also effective in Africa. In HIV immunosuppressed people who are coinfected with leishmaniasis it has shown that even in resistant cases 2/3 of the people responded to this new treatment. Clinical trials in Colombia showed a high efficacy for cutaneous leishmaniasis. In mucocutaneous cases caused by L.brasiliensis it has shown to be more effective than other drugs.Miltefosine received approval by the Indian regulatory authorities in 2002 and in Germany in 2004. In 2005 it received the first approval for cutaneous leishmaniasis in Colombia. Miltefosine is also currently being investigated as treatment for mucocutaneous leishmaniasis caused by Leishmania braziliensis in Colombia, and preliminary results are very promising.

Source: Wikipedia > Leishmaniasis