Any variation from the standard karyotype may lead to developmental abnormalities.
Levitsky seems to have been the first to define the karyotype as the phenotypic appearance of the somatic chromosomes, in contrast to their genic contents. Levitsky G.A. 1924.
The diploid number of the Chinese muntjac, Muntiacus reevesi , was found to be 46, all telocentric. When they looked at the karyotype of the closely related Indian muntjac, Muntiacus muntjak , they were astonished to find it had female = 6, male = 7 chromosomes. Wurster D.H. and Benirschke K. 1970. Indian Muntjac, Muntiacus muntjak : a deer with a low diploid number.
Source: Wikipedia > Karyotype
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