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Sometimes negative cross resistance occurs, where resistance to one chemical class of fungicides leads to an increase in sensitivity to a different chemical class of fungicides. This has been seen with carbendazim and diethofencarb.

For example Botrytis cinerea is resistant to both azoles and dicarboximide fungicides.

The most common mechanism appears to be alteration of the target site, particular as a defence against single site of action fungicides. For example Black Sigatoka, an economically important pathogen of banana, is resistant to the QoI fungicides, due to a single nucleotide change resulting one amino acid (glycine) being replaced by another (alanine) in the target protein of the QoI fungicides, cytochrome b. Sierotzki, Helge (2000) Mode of resistance to respiration inhibitors at the cytochrome bc1 enzyme complex of Mycosphaerella fijiensis field isolates Pest Management Science 56 :833-841 This presumably disrupts the binding of the fungicide to the protein, rendering the fungicide ineffective.

Far fewer fungicides have curative/eradicative ability than protectant. Thus fungicide preparations advertised as having curative action may only have one active chemical; a single fungicide acting in isolation increases the risk of fungicide resistance.

Source: Wikipedia > Fungicide