Etiology Topics

• epstein barr virus
• nasopharyngeal carcinoma
• sophisticated statistical analysis
• acid secretion
• ulcer disease
• etiological agent
• chronic diseases
• pylori infection
• experimental evidence
• mononucleosis
• helicobacter pylori
• causation
• infectious diseases
• compelling evidence
• risk factors
• epidemiological
• carcinoma
• lymphoma
• promoter
• interventions

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Etiology, Etiology

But proof of causation in infectious diseases is limited to individual cases that provide experimental evidence of etiology.

Events may occur together simply due to chance, bias or confounding, instead of one event being caused by the other. It is also important to know which event is the cause. Careful sampling and measurement are more important than sophisticated statistical analysis to determine causation. Experimental evidence, involving interventions (providing or removing the supposed cause), gives the most compelling evidence of etiology.

An etiological agent of disease may require an independent co-factor, and be subject to a promoter (increases expression) to cause disease. An example of all the above, which was recognized late, is that peptic ulcer disease may be induced by stress, requires the presence of acid secretion in the stomach, and has primary etiology in Helicobacter pylori infection. Many chronic diseases of unknown cause may be studied in this framework to explain multiple epidemiological associations or risk factors which may or may not be causally related, and to seek the actual etiology.

Conversely, one etiology, such as Epstein-Barr virus, may in different circumstances produce different diseases, such as mononucleosis, or nasopharyngeal carcinoma, or Burkitt's lymphoma.

Source: Wikipedia > Etiology