Cysticercosis Topics

• am j trop med hyg
• johns hopkins university
• world health organization
• emerging infectious diseases
• international conference on emerging infectious diseases
• human feces
• disease eradication
• cyst stage
• chemotherapy treatment
• oxfendazole
• taenia solium
• comparative trials
• gavidia
• meta analysis
• praziquantel
• negl
• vcw
• schantz
• verastegui
• garca

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Cysticercosis, Cysticercosis

Matthaiou, Georgios Panos, Eleni S. Adamidi,Matthew E. Falagas Albendazole versus Praziquantel in the Treatment of Neurocysticercosis: A Meta-analysis of Comparative Trials PLoS Negl Trop Dis. 2008 March; 2(3): e194 In the case of brain parenchymal cysticercosis, treatment depends on the stage of cyst development. In immature cyst stage (stage 1), high-dose corticosteroids are administered to reduce the edema but antihelminth drugs have been found to be harmful.

World Health Organization 2007 . International Task Force for Disease Eradication in 1992 reported that cysticercosis is potentially eradicable.

The only source of T.solium infection for pigs is from humans, a definite host. Theoretically, breaking the life cycle seems easy by doing intervention strategies from various stages in the life cycle.. Schantz, P. Eradication of T.solium Cysticercosis International Conference on Emerging Infectious Diseases 2002. CDC. ftp://ftp.cdc.gov/pub/infectious_diseases/iceid/2002/pdf/schantz.pdf For example,(a) Massive chemotherapy treatment of infected humans, improving sanitation, and education humans are major ways to discontinue the cycle at step 1, in which eggs from human feces are transmitted to other humans and/or pigs.(b) Cooking of pork or freezing it and inspecting meat are effective means to cease the life cycle at step 3.(c) The management of pigs by treating them or vaccinating them is another possibility to intervene step 4 of the life cycle.

Gonzalez AE, Garca HH, Gilman RH, Tsang VCW, Cysticercosis Working Group in Peru.

Gonzalez, A.E., Gavidia, C., Falcon, N., Bernal, T., Verastegui, M., Garcia, H.H., Gilman, R.H., Tsang, V.C., 2001.Protection of pigs with cysticercosis from further infections after treatment with oxfendazole. Am. J. Trop. Med. Hyg.65, 15-18.

Effectiveness of an interventional control program for human and porcine Taenia solium cysticercosis in field conditions. In: International Health. Johns Hopkins University, Baltimore, p. 250.

In 1983, Molinari et al. reported the first vaccine candidate against porcine cysticercosis using antigen from cysticercus cellulosae drawn out from naturally infected.

Some studies suggest that the prevalence of cysticercosis in Mexico is between 3.1 and 3.9 percent. Other studies have found the seroprevalence in areas of Guatemala, Bolivia, and Peru as high as 20 percent in humans, and 37 percent in pigs. http://virtualmentor.ama-assn.org/2008/04/cprl1-0804.html In Ethiopia, Kenya and the Democratic Republic of Congo around 10% of the population is infected, in Madagascar 16%. The frequency has decreased in developed countries owing to stricter meat inspection, better hygiene and better sanitary facilities. The distribution of cysticercosis coincides with the distribution of T.solium.

Current livestock for pigs in the U.S do not play a role in the transmission of Taenia solium, and thus cysticercosis in the U.S is an imported disease.

Source: Wikipedia > Cysticercosis