Chloracne, Chloracne

It was only in the mid-1950s that chloracne was associated with aromatic hydrocarbons . The substances that may cause chloracne are now collectively known as chloracnegens.

The severity and onset of chloracne may follow a typical asymptotic dose-response relationship curve.

Chloracne is a chronic inflammatory condition that results from this persistence, in combination with the toxin's chemical properties. It is believed, at least from rodent models, that the toxin activates a series of receptors promoting macrophage proliferation, inducing neutrophilia and leading to a generalised inflammatory response in the skin. This process may also be augmented by induction of excess tumor necrosis factor in the blood serum.

Source: Wikipedia > Chloracne