Brca2, Brca2

The proteins made by both genes are essential for repairing damaged DNA. The BRCA2 protein binds to and regulates the protein produced by the RAD51 gene to fix breaks in DNA. These breaks can be caused by natural and medical radiation or other environmental exposures, but also occur when chromosomes exchange genetic material during a special type of cell division that creates sperm and eggs (meiosis). The BRCA1 protein also interacts with the RAD51 protein. By repairing DNA, these three proteins play a role in maintaining the stability of the human genome and prevent dangerous gene rearrangements that can lead to a hematologic cancers 4. Friedenson B. (2008) http://www.dnatube.com/video/1384/The-BRCA12-pathway-prevents-leukemias-and-lymphomas Like BRCA1, BRCA2 probably regulates the activity of other genes and plays a critical role in embryo development.

As a result of these mutations, the protein product of the BRCA2 gene is abnormal and does not function properly. Researchers believe that the defective BRCA2 protein is unable to help fix mutations that occur in other genes. As a result, mutations build up and can cause cells to divide in an uncontrolled way and form a tumor.

Source: Wikipedia > Brca2