Basophil Topics

• interleukin 4
• mast cell
• environmental substances
• basophilia
• basophils
• t cells
• granulocytes
• cell surface
• leukaemia
• cytokines
• antibody
• immune response
• receptors
• allergic reaction
• inflammation
• ige
• lymphoma
• immune system
• pollen
• proteins

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The mast cell, a cell in tissues, has many similar characteristics. For example, both cell types store histamine, a chemical that is secreted by the cells when stimulated in certain ways (histamine causes some of the symptoms of an allergic reaction). Like all circulating granulocytes, basophils can be recruited out of the blood into a tissue when needed.

Basophils have protein receptors on their cell surface that bind IgE antibody very tightly. It is the bound IgE antibody that confers a selective response of these cells to environmental substances, for example, pollen proteins. Recent studies in mice suggest that basophils may also regulate the behavior of T cells and mediate the magnitude of the secondary immune response.

Each of these substances contributes to inflammation. Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4, perhaps more important than T cells. Interleukin-4 is considered one of the critical cytokines in the development of allergies and the production of IgE antibody by the immune system. There are other substances that can activate basophils to secrete which suggests that these cells have other roles in inflammation.

Basophilia is also uncommon but may be seen in some forms of leukaemia or lymphoma.

Source: Wikipedia > Basophil Granulocyte